Hair loss myths: 7 common misconceptions about hair loss and balding.
Body mass index was defined as weight kg divided by height squared m 2. A mercury sphygmomanometer was used to measure blood pressure BP in the sitting position after a minute rest period. Two readings of systolic and diastolic BP were recorded at 3-minute intervals, and averages were included in the analysis.
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After 12 and 24 weeks of treatment, patient self-assessment of the efficacy of the treatment self-rated improvement score was based on a self-administered hair growth, using a Visual Analogue Scale VAS , ranging from zero representing the worst imaginable state to 10 the best imaginable state. Self-rated satisfaction with treatment was also measured using a point VAS with 0 and 10 representing the lowest and highest satisfaction level, respectively.
Pictures were taken of the vertex and superior frontal scalp of each patient at baseline and after 24 weeks of treatment using a standardized technique, as previously described [ 14 ]. A blinded investigator rated changes in scalp appearance relative to baseline immediately prior to treatment commencement in blinded fashion using a standardized 7-point rating scale as follows: Investigator assessments were performed at 12 and 24 weeks.
Hair analysis using a phototrichography was performed by one technician. At baseline, the most severe site of baldness was recorded as target area of hair changes and the center of the phototrichogram probe was placed at this site. After 12 and 24 weeks of treatment, hair analysis was performed with confirmation of recorded target area.
The primary outcome variables were blinded investigator assessment and patient self-assessment scores. Secondary outcomes variables were changes in hair thickness and hair count. When test data was unavailable, the last recorded data entry was entered in the analysis the last observation carried forward method.
Efficacy analysis was performed on an intention to treat ITT basis on participants that received at least one dose of PSO or placebo and that underwent at least one assessment postbaseline. The D'Agostino Pearson test was used to test for variable normality. Intergroup comparisons of baseline characteristics and of their changes after 24 weeks of treatment were performed using the two-sample Student's t -test for continuous variables or the chi-square test for categorical variables.ilearntennis.com/wp-content/321/rahe-leute-in-der.php
Alternative Medicine for Hair Loss
Intragroup comparisons were performed using the paired Student's t -test. P values of less than 0. Furthermore, no statistically significant intergroup differences were observed for age at the onset of hair loss, family history of alopecia, or laboratory data at baseline. During the study period, the double-blind requirement was well maintained.
Clinical and biochemical characteristics at the start of the study and after 24 weeks of treatment. However, after 24 weeks, the self-rated improvement score in the intervention group was higher than in the control group 3. In addition, group self-rated satisfaction scores were also significantly different at 24 weeks 3. In the control group, there was no initial improvement during the first 12 weeks, and then hair growth plateaued during the second 12 weeks Figure 1.
At 24 weeks, 2. On the other hand, at 24 weeks, Investigator assessment of clinical response using a standardized 7-point rating scale during 24 weeks after study start. Data are expressed as mean with SE. Photographs of scalp hair were taken for hair counts and for assessments of hair growth by an expert panel.
Representative photographs of patients at baseline and after 24 weeks of treatment with PSO. Hair changes, that is, hair counts and hair diameters, were measured by phototrichography at baseline and at 12 and 24 weeks.
Changes in hair count a and thickness b during 24 weeks after study start. Data are expressed as mean with SD. Most of the subjects completed the protocol without adverse symptoms. One subject in the intervention group and one subject in the control group complained of a whole body itching sensation. One subject in the intervention group complained of mild abdominal discomfort.
Hair loss - Diagnosis and treatment - Mayo Clinic
No changes in liver enzyme or creatinine were observed in the intervention group. Serum-free testosterone levels were unchanged in both groups Table 3. No intergroup differences in blood pressure or glucose were observed during the study period Table 4. Data are expressed as frequency percent. To our knowledge, this is the first randomized, double-blind, placebo-controlled trial to investigate the efficacy and tolerability of PSO in men with mild to moderate AGA. This study shows that PSO supplement during 24 weeks has a positive anabolic efect on hair growth and that this is due to the possible efects of 5-reductase inhibition in patients with mild to moderate male pattern hair loss.
AGA is the most common type of hair loss to affect both males and females after puberty. Although AGA is not a serious health problem, there is a strong demand for treatment and prevention due to the high level of interest people have in personal appearance in modern society. It is well known that finasteride and minoxidil are effective treatments for androgenetic alopecia and both have been approved by the FDA for this purpose, but some patients do not like taking medicine in the long term, because of possible side effects.
For example, finasteride can decrease libido and ejaculate volume or cause erectile dysfunction, whereas minoxidil can cause scaling and itching of the scalp [ 6 , 7 ]. Herbal therapies have been used to treat baldness since ancient times in the Ayurveda, Chinese, and Unani traditional medicinal systems [ 4 ]. Natural products, such as grape seed and rosemary oil, have been shown to be possible alternative treatments for AGA due to improved scalp blood flow [ 16 , 17 ].
Soymetide-4 was one of the herbal product-suppressing alopecia and ginseng Panax ginseng was also used for scalp treatment limiting hair loss with anti-inflammatory and blood circulation effect [ 19 , 20 ]. Eclipta alba extract and Zizyphus jujuba essential oil showed possibility of alternative treatment of alopecia [ 21 , 22 ]. Saw palmetto Serenoa repens has been used as a natural treatment for androgenetic alopecia and has a similar mechanism [ 23 ]. The authors concluded that it could be used as an alternative treatment for mild to moderate AGA and that it is more effective than finasteride in this respect [ 24 ].
It has been reported in several animal studies that PSO inhibits testosterone-induced hyperplasia of the prostate and suggested that PSO may be beneficial for the management of BPH [ 10 , 24 ]. Our study has some limitations, which include a lack of histological confirmation of the action mechanism of PSO. The final limitation is degree of accuracy when assessing changes of hair by phototrichography, even though hair analysis was performed with confirmation of recorded target area in baseline.
Nevertheless, our results have a value because current study was conducted based on the randomized controlled trials which evaluated hair changes using photographs as well as phototrichography. Despite of these limitations, this double-blinded study did involve 76 subjects and, to the best of the authors' knowledge, is the first study to examine the long-term efficacy of PSO on AGA.
However, replication will be needed in order to confirm the results of this first-stage study and additional studies are required to elucidate the mechanism responsible for the positive effects of PSO on AGA. National Center for Biotechnology Information , U. Evid Based Complement Alternat Med. Published online Apr Author information Article notes Copyright and License information Disclaimer.
Received Feb 13; Accepted Apr 4. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Abstract Pumpkin seed oil PSO has been shown to block the action of 5-alpha reductase and to have antiandrogenic effects on rats.
Materials and Methods 2. Study Design This study had a randomized, placebo-controlled, double-blind, controlled design. Randomization Participants were assigned to the intervention and control groups using random numbers tables, and assigned identification numbers on recruitment. Measurements Body mass index was defined as weight kg divided by height squared m 2. Patient Self-Assessment After 12 and 24 weeks of treatment, patient self-assessment of the efficacy of the treatment self-rated improvement score was based on a self-administered hair growth, using a Visual Analogue Scale VAS , ranging from zero representing the worst imaginable state to 10 the best imaginable state.
Investigator Assessments Pictures were taken of the vertex and superior frontal scalp of each patient at baseline and after 24 weeks of treatment using a standardized technique, as previously described [ 14 ]. Statistical Analysis The primary outcome variables were blinded investigator assessment and patient self-assessment scores. Table 1 Basal characteristics of subjects. Open in a separate window. Dr Edward Ball, a leading UK hair transplant surgeon from specialist London centre The Maitland Clinic, helps to debunk some myths - while untangling the truth behind others.
It has been said that rubbing onion juice on the scalp twice a week for two months can help bring dormant hair follicles back to life. As a surgeon, my natural instinct is to be cynical of home remedies that have no founding in scientific research. The small green fruit, similar in appearance to a grape, is said to have astonishing health boosting properties which will prevent greying and thinning hair. Followers of Ayurvedic medicine - an ancient holistic healing system - believe that amla can keep people youthful and radiant for up to years.
But it alone is very unlikely to have any impact on hair loss. While most people think of liquorice as a sweet, the plant - liquorice root - is said to help many ailments including asthma, ulcers, arthritis, and hair loss. Fenugreek is celebrated for its healing properties. The seeds are said to help cure many conditions, including hair loss.