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Not one company was willing to take a chance on a non-CD19 target. The obvious answer is that it's the low hanging fruit of the CAR world. There is no question that CDspecific CAR T cells can effectively treat a variety of liquid tumors and will be approved for a handful of indications as a second or third line therapy.

The Cellectis slide suggests that there is a long list of targets which are selectively expressed on tumor cells at low levels which were previously inaccessible.

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What investors should be asking now is, what are these targets? The following is a list of non-CD19 CAR T clinical studies, based on a Google Scholar search using the terms "chimeric antigen receptor" and "clinical: Ultimately resistance to the treatment developed, the cancer flourished again, and the patient died. There were some interesting correlations, but overall survival was disappointing.

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TBubble Clean focuses on bettering Android phone performance. With its four major roles of speed booster, junk file cleaner, phone cooler and battery saver, it allows your phone to run smoothly all the time. TBubble Clean could clean the junk files, idle storage and useless large files from millions of apps, thus releasing plenty of free space.


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